Selective reduction of aromatic ketones in aqueous medium m by Ti(III)/Mn: A revised mechanism.
- Antonio Rosales,
- Juan Muñoz-Bascón,
- Esther Roldan-Molina,
- Mayra A. Castañeda,
- Natalia M. Padial,
- Andreas Gansäuer,
- Ignacio Rodríguez-García, and
- J. Enrique Oltra
An experimental study on the role played by each of the reagents involved in the selective reduction of aromatic ketones in aqueous medium is reported. In this reaction, the reduction of aromatic ketones is mediated by Cp2TiCl. Moreover, the presence of Mn in the reaction medium is mandatory. To account for these findings, a substantially revised mechanism is proposed.
Published in: J. Org. Chem., 2014, 79 (16), pp 7672–7676, DOI: 10.1021/jo501141y